Standardization trigger

It is to be hoped that this and some other remaining discrepancies will be addressed in the next revision of the Annex 1 to the EU GMP guide. This example illustrates how one round of harmonization or standardization triggers a new round of changes in other sets of standards. 

Figure 10 shows an example of how the algorithm STA/LTA works for the standard trigger using the absolute value. 

Standard triggers of a toxic release for emergency personnel (STEP) ambulance services use the following simple guidance to determine whether a toxic release may have taken place in the case of one or more casualties. 

Many compounds explode when triggered by a suitable stimulus however, most are either too sensitive or fail to meet cost and production-scale standards, requirements for safety in transportation, and storage stability. Propellants and explosives in large-scale use are based mosdy on a relatively small number of well-proven iagredients. Propellants and explosives for military systems are manufactured ia the United States primarily ia government owned plants where they are also loaded iato munitions. Composite propellants for large rockets are produced mainly by private iadustry, as are small arms propellants for sporting weapons. 

Offsets Policy Offsets were EPAs first application of the concept that one source could meet its environmental protection obligations by getting another source to assume additional control actions. In nonattainment areas, pollution from a proposed new source, even one that controls its emissions to the lowest possible level, would aggravate existing violations of ambient air-quahty standards and trigger the statutory prohibition. The offsets policy provided these new sources with an alternative. The source could proceed with construction plans, provided that ... 

The gaseous emissions from the FCC unit are CO, NOj, particulates, and SOj. All are either locally or nationally regulated. Table 10-7 shows the current allowable limits of the EPA New Source Performance Standards (NSPS) for the emissions of these airborne pollutants. NSPS levels can be triggered by one of the following conditions ... 

Non-motor signs of the disorder are also treatable with symptomatic medications. The frequent mood disorder can be treated with standard antidepressants, including tricyclics (such as amitryptiline) or serotonin reuptake inhibitors (SSRIs, such as fluoxetine or sertraline). This treatment is not without risks in these patients, as it may trigger manic episodes or may even precipitate suicide. Anxiety responds to benzodiazepines, as well as to effective treatment of depression. Long-acting benzodiazepines are favored over short-acting ones because of the lesser abuse potential. Some of the behavioral abnormalities may respond to treatment with the neuroleptics as well. The use of atypical neuroleptics, such as clozapine is preferred over the typical neuroleptics as they may help to control dyskinesias with relatively few extrapyramidal side-effects (Ch. 54). 

A plant had a runaway reaction with a phenol-formaldehyde polymerization reaction. The result was one fatality and seven injuries and environmental damage. The runaway reaction was triggered when, contrary to standard operating procedures, all the raw materials and... 

The well balanced electronic and coordinative unsaturation of their Ru(II) center accounts for the high performance and the excellent tolerance of these complexes toward an array of polar functional groups. This discovery has triggered extensive follow up work and carbenes 1 now belong to the most popular metathesis catalysts which set the standards in this field [3]. Many elegant applications to the synthesis of complex target molecules and structurally diverse natural products highlight their truely remarkable scope. 

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