Stabilizers, oral care products

Pullulan is a polysaccharide obtained from the fermentation of starch by the yeast Aurobasidiutn pullulans. It is edible and tasteless. It is used as edible films for food packaging with high oxygen permeability, oral care products, adhesives, thickeners, stabilizers, etc.. 

The broad activity spectrum of Triclosan, its stability, its good skin compatibility and favourable toxicological profile make the microbicide to an ideal active ingredient for skin care and oral care products, for hand surface disinfectants, for household products and for the antimicrobial treatment of polymers. 

Clement, S. Still, J.G. Kosutic, G. McAllister, R.G. Oral insulin product hexyl-insulin monoconjugate 2 (HIM2) in type 1 diabetes mellitus the glucose stabilization effects of HIM2. Diabetes Technol. Ther. 2002, 4 (4), 459 66. Kipnes, M. Dandona, P. Tripathy, D. Still, J.G. Kosutic, G. Control of postprandial plasma glucose by an oral insulin product (HIM2) in patients with type 2 diabetes. Diabetes Care 2003, 26 (2), 421 26. 

The arguments offered above call for caution and the careful, however scientifically sound, evaluation of the safety of food items for human consumption. Close toxicological and pharmacological surveillance of nutritional products with additives and/or the history of chemical or physical processing is of paramount importance. The importance of this surveillance is demonstrated most convincingly by observations made recently in the field of hyperalimentation. Here the patient, deprived of the ability of oral food intake, is dependent on the intravenous infusion of solutions of essential amino acids. For solution stabilization sodium bisulfite was added. This presumed preservative, however, reacts with tryptophan (20) with the formation of products which affect liver tissue adversely (21). 

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