Fluid bed spray granulation

Because of their ability to deposit multiple layers of solids on a given par- 

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The various components of a typical fluid bed spray granulation unit are depicted in Fig. 7.8. Fluidizing gas (usually air) at 2 or 3 psig (14 to 21 kPa) is heated externally to the fluid bed and passes to the base of the unit. Here a suitable distributor such as a perforated plate or tubes with nozzles passes the gas to the particle bed uniformly over its cross-section. Jets formed at... 

Characteristics of batch fluid bed spray granulators to produce tablet granulations in the pharmaceutical industry. Flowsheet given in Fig. 7.9. 

Fig. 7.9. Batch fluid bed spray granulator used to produce tablet granulations in the pharmaceutical industry. Air-flow necessary for fluidization is generated by a suction-fan (2) mounted in the top portion of the unit, directly driven by an electric motor. The air being used is heated to the desired temperature by an air heater (5). Prefilters remove all impurities at the air inlet (6). The material to be processed has been loaded into the material container (1). The container bottom consists of a perforated plate above which a fine mesh stainless steel retaining screen is fitted. Exhaust filters (7) mounted above the product container retain fines and dust. The granulating liquid (3) is sprayed as a fine mist through a mechanical or pneumatically actuated nozzle (4) onto the finely dispersed, fluidized material to form the desired agglomerates. (Courtesy Aeromatic AG.)...

Fluid bed spray granulation ceramic pressbodies, 155, 156 comparison with spouted bed process, 158... 

Figure 161. Typical flow diagram of a continuous Niro fluid bed spray granulation process for the solidification of solids in solutions, suspensions, or melts. (Explanations, see text)...

Fig. 7.79 Batch fluid bed spray granulator system. (1) Air filter and heater, (2) powder batch/fluidized bed, (3) spray nozzle, (4)/(5) liquid feed tank and pump, (6) bag filter, (7) exhaust fan (courtesy CEA/NIRO, Soeborg, Denmark).

Tab. 10-5 Troubleshooting fluid bed spray granulators (adapted from an unpublished guideline by Niro, Inc., Columbia, MD, USA)...

Tab. 10-5 Troubleshooting fluid bed spray granulators (adapted from an rmpublished guideline by Niro, Inc., Columbia, MD, USA) Tab. 11.1 Some major effects of decreasing size on properties of fine and ultrafme (nano) particles [B.97, 11.1]...

Engelleitner, W. H. 1994. Method Comparison. Notes of Course on Briquetting, Pelletizing, Extrusion, and Fluid Bed/Spray Granulation. The Center for Professional Advancement. Chicago, IL. 

It is, however, very difficult to reproduce such a process. Therefore, an alternative procedure to manufacture effervescent granules has been invented using a rotor fluid bed spray-granulator (32). 

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