Sporadic disease

O Ovarian cancer is a sporadic disease fewer than 10% of ovarian cancers can be attributed to heredity. 

O Ovarian cancer is a sporadic disease fewer than 10% of ovarian cancers can be attributed to heredity. Most cases of ovarian cancer occur sporadically, thus making it difficult to screen and prevent. Although heredity accounts for less than... 

Lou Gehrig s disease (amyotrophic lateral sclerosis ALS) displays motor neuron deposits of hyperphosphorylated neurofilament subunits in the sporadic disease. Familial ALS, some 20% of all cases of ALS, involves dominant superoxide dismutase SOD1 mutants that can form (3-barrel aggregates [49-51]. 

It is an aerobic, gram-negative, nonmotile, nonsporing, rod-shaped bacterium. It can survive in the environment for up to 2 months in sheltered positions. It is normally a disease of horses. It is a rare and sporadic disease in humans, but it is transmissible by direct contact with sick animals or infected materials. The natural reservoirs are horses, donkeys, and mules. This is a biosafety level 3 agent. 

Frontotemporal dementias occur as familial forms and, more commonly, as sporadic diseases. They are characterized by a remarkably circumscribed atrophy of the frontal and temporal lobes of the cerebral cortex, often with additional, subcortical changes. In 1994, an autosomal-dominantly inherited form of frontotemporal dementia with parkinsonism was linked to chromosome 17q21.2. Subsequently, other forms of frontotemporal dementia were linked to this region, resulting in the denomination frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) for this class of disease. All cases of FTDP-17 have so far shown a filamentous pathology made of hyperphosphorylated tau protein (Fig. 45-7). In 1998, mutations in tau were reported in FTDP-17 patients [29-31]. Since then, more than 30 different mutations have been described in over 80 families with FTDP-17 (Fig. 45-6). 

Rosellinia. Among cacao root rots, that caused by the Rosellinia fungus is a sporadic disease that occurs mainly in poorly drained soils. 

MTC occurs as a sporadic disease and as part of the syndromes of MEN-2A, MEN-2B, and familial MTC (EMTC). "" MEN-2A and MEN-2B are autosomal dominant inherited multiglandular syndromes with age-related penetrance and variable expression. AH forms of MTC combined account for 5% to 10% of thyroid malignancies. Sporadic MTC is believed to comprise approximately 75% of all MTC. The routine measurement of serum calcitonin in nodular thyroid diseases assists in detecting unsuspected sporadic With the advent of... 

Prion diseases are traditionally grouped according to their route of acquisition, as sporadic, familial, or infectious diseases. While sporadic disease variants predominate in humans, no such prion disease has yet been formally identified in animals. 

Shingles Sporadic disease caused by reactivation of varicella-zoster herpesvirus that... 

Sporadic disease A disease that is limited to a small number of isolated case posing no great threat to a large population. 

Within a population there is a proportion of individuals who are predisposed to develop cancer, either as an apparently sporadic disease or in response to an environmental challenge, such as exposure to tobacco smoke or ionising radiation. The abnormally high frequency of some tumor types within related members of large famihes provided evidence that cancer is, in some circumstances, a heritable disease. Genetic linkage studies of these famihes has revealed that a number of these cancer syndromes occur as simple Mendelian traits, usuaUy with a highly penetrant dominant pattern of inheritance. 

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