Sponges Agelas nakamurai

Bromopyrrole-2-carbamide (116) was isolated from the Papua New Guinean sponge Agelas nakamurai. It exhibits antimicrobial activity against Staphylococcus aureus (IC50 0.78 pg/ml) and other bacteria and fungi [92]. 

Most of the known natural brominated pyrrole alkaloids are found in sponges, and several new examples were isolated since the first survey (1). Reviews are available that discuss the occurrence and syntheses of these metabolites (1236-1238). The Papua New Guinea sponge Agelas nakamurai has yielded the new simple pyrroles 1222 and 1223 (1239). The dibromo analog (1224) of 1223 along with enantiomeric lactams 1225/1226, which were separated by chiral HPLC, and... 

Iwagawa T, Kaneko M, Okamura H, Nakatani M, van Soest RWM (1998) New Alkaloids from the Papua New Guinean Sponge Agelas nakamurai. J Nat Prod 61 1310... 

Uemoto H, Tsuda M, Kobayashi J (1999) Mukanadins A-C, New Bromopyrrole Alkaloids from Marine Sponge Agelas nakamurai. J Nat Prod 62 1581... 

Meketa ML, Weinreb SM (2006) Total Synthesis of Ageladine A, an Angiogenesis Inhibitor from the Marine Sponge Agelas nakamurai. Org Lett 8 1443... 

Mukanadins A (10) and B (12) have been isolated from the Okinawan sponge Agelas nakamurai [33] actually, the structure of mukanadin A corresponds to that of... 

Two sceptrin-related compounds, nakamuranic acid (73) and its corresponding methyl ester (74), have been isolated from the Indo-Pacific sponge Agelas nakamurai [114,115],... 

Ageladine A (84), from the sponge Agelas nakamurai, is the first isolated pyrrole-imidazole alkaloid containing a 2-aminoimidazolopyridine moiety [78]. 

Meketa, M. L. Weinreb, S. M. 2006. Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge agelas nakamurai. Org. Lett. 8 1443-1446. 

Nakamura, H., Wu, H., Kobayashi, J., Kobayashi, M., Ohizumi, Y, and Hirata, Y. (1985) Agelasidines, novel hypotaurocyamine derivatives from Okinawan Sea sponge Agelas nakamurai Hoshino. J. Org. Chem., 50, 2494-2497. 

Shoji, N., Umeyama, A., Teranaka, M., and Arihara, S. (1996) Four novel diterpenoids, including nakamurol A with a unique fhelepogane skeleton, from fhe marine sponge Agelas nakamurai. J. Nat. Prod., 59, 448-450. 

Tsuda, M., Uemoto, H., and Kobayashi, J. (1999b) Slagenins A-C, novel bromopyrrole alkaloids from marine sponge Agelas nakamurai. Tetrahedron Lett., 40, 5709-5712. 

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