Splicing silencers

Also known as transcription repression results from the interaction of cis-and fran.y-components/sequences to inhibit the process of transcription of mRNA. Distinct from splicing silencing. See Nasmyth, K. and Shore, D.,... 

Cartegni L, Chew SL, Krainer AR. Listening to silence and understanding nonsense Exonic mutations that affect splicing. Nat Rev Genet 2002 3 285-298. 

Besides its traditional role in mRNA, tRNA, and rRNA, RNA serves other functions, such as splicing reactions, trimming reactions, and the peptide synthesis reaction of peptidyl transferase. It also has been shown that some small RNAs are produced they act as gene silencers by binding to specific DNA sequences and blocking their transcription. 

In contrast, hnRNPs mainly interact with silencer sequences to prevent splicing or promote exon skipping. 

MOs targeting the same gene can also eliminate off-target effects, especially when one translation-silencing MO and one splicing-inhibiting MO are used in combination. 

---