Spinal cord regeneration

Heteroatom biodegradable and electrically conducting polymers, (IV), effective for tissue engineering applications were prepared by Schmidt [4] and used in spinal cord regeneration, wound healing, and bone repair. 

Schwab JM, Brechtel K, Mueller CA, Failli V, Kaps HP, TuU SK, Schluesener HJ (2006) Experimental strategies to promote spinal cord regeneration—an integrative perspective. Prog Neurobiol 78 91-116... 

The holy grail of all these efforts is the restoration of movement to the paralyzed. For example, quadriplegics need to use their hands, and cortical control of functional neuromuscular stimulation devices would appear to be the answer to this need. These systems, though they will provide access to cortical control signals, may not alone restore movement to those with spinal cord injury instead, I suspect these recording technologies will be hybridized with spinal cord regeneration efforts to restore movement to... 

Maquet, V., Martin, D., Scholtes, F., Franzen, R., Schoenen, J., Moonen, G., and Jerome, R. (2(X)1), Poly(D,L-lactide) foams modified by poly(ethylene oxide)-block-poly(D4 lactide) copolymers and a-FGF In vitro and in vivo evaluation for spinal cord regeneration. Biomaterials 22(10) 1137-1146. 

Zamani, F., Amani-Tehran, M., Latifi, M., Shokrgozar, M.A., Zaminy, A., 2014. Promotion of spinal cord regeneration by 3D nanofibrous core-sheath scaffolds. J. Biomed. Mater. Res. A 102 (2), 506-513. 

PHAs have been explored for many different biomedical applications [30]. P(3HB) and P(4HB) fibers have been evaluated in animal models for suture applications [31]. Nonwoven webs of P(3HB) and P(4HB) fibers have been studied for use in nerve repair conduits [32, 33]. P(3HB) fibers have been investigated as the carrier scaffold to promote axonal migration and help spinal cord regeneration [34]. Due to its piezoelectric activity, P(3HB) is a promising candidate as a scaffold material for bone regeneration. Some studies have indicated a favorable osteogenic response to P(3HB) [35, 36]. P(4HB) fibers and multifilament yams... 

Jones, DG, Anderson, ER, and Galvin, KA. 2003. Spinal cord regeneration Moving tentatively towards new perspectives. NeuroRehabilitation 18 339-351. 

Tabesh, H, Amoabediny, G, Nik, NS et al. 2009. The role of biodegradable engineered scaffolds seeded with Schwann cells for spinal cord regeneration. Neurochem Int 54(2) 73-83. 

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