Spermatogonial stem cell

A few chemicals have been found to induce specific-locus mutations in spermatogonial stem cells, and ethyl nitrosourea (ENU) is extremely effective. At the highest dose studied, an average of 1 of 141 offspring has a... 

Ethylene oxide was ineffective in inducing morphological-specific locus mutations in spermatogonial stem cells however, it produced dominant visible and electro-phoresis-specific locus mutants in male mice, assumed to be derived from poststem cells. 

Falciatori I, Borsellino G, Haliassos N, et al. (2004). Identification and enrichment of spermatogonial stem cells displaying side-popnlation phenotype in immatnre mouse testis. Faseb. J. 18 376-378. 

Primordial germ cells and spermatogonial stem cells cryopreservation... 

Kanatsu-Shinohara M, Takashima S, Ishii K et al (2011) Dynamic changes in EPCAM expression during spermatogonial stem cell differentiation in the mouse testis. PLoS One 6 e23663... 

E. F. Oakberg, A new concept of spermatogonial stem-cell renewal in the mouse and its relationship to genetic effects. Mutation Res. 11, 1-7 (1971). 

C. Huckins, The spermatogonial stem cell population in adult rats, 1. Their morphology, proliferation and maturation, Anat. Rec. 169, 533-558 (1971). 

The recent identification of the cytotoxicity of silver nanoparticles towards a spermatogonial stem cell tine has aroused great concern over the biosafety of nanomaterials [107]. As discussed previously, the liver appears to be an eventual accumulation site for circulatory silver nanoparticles, and similar patterns of cytotoxicity for silver nanoparticles (decreased mitochondrial function, lactate dehydrogenase (LDH) leakage and abnormal cell morphologies) were observed in vitro. Nonetheless, during other experiments using nanosilver, a variety of... 

Figure 6.2 Morphology of C18-4 spermatogonial stem cells after incubation with silver nanoparticles (diameter 15 nm concentration lOpgml ) for 48 h. The arrows indicate the intact plasma membrane. (Reproduced with permission from Ref. [13] 2005 Oxford University Press).

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