Spermatogonial chromosome aberration test

Mammalian Spermatogonial Chromosome Aberration Test (Original Guideline, adopted 21 July 1997)... [Pg.21]

Mammalian spermatogonial chromosomal aberration test (August 1998)... [Pg.26]

Positive results in the in vivo mammalian spermatogonial chromosome aberration test indicate that a substance induces structural chromosome aberrations in the germ cells of the species tested. This test measures chromosome events in spermatogonial germ cells and is, therefore, expected to be predictive of induction of inheritable mutations in germ cells. [Pg.160]

Mammalian spermatogonial chromosome aberration test (OECD 483) Spermatid micronucleus assay... [Pg.160]

Mammalian spermatogonial chromosome aberration test Mammalian spermatogonial chromosome Inheritable chromosome aberrations B23/TG483... [Pg.447]

OECD, 1997f, Test Guideline 483, Mammalian Spermatogonial Chromosome Aberration Test. OECD, 1997g, OECD Test Guideline 486. Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo. [Pg.459]

The spermatogonial test is used to identify substances that cause structural chromosome aberrations in mammalian spermatogonial cells, and is designed to investigate whether somatic cell mutagens are also active in germ cells. This test is not designed to measure numerical aberrations and is not routinely used for this purpose. [Pg.149]

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