Spermatogenesis chromatin

Drabent B, Saftig P, Bode C, Doenecke D (2000) Spermatogenesis proceeds normally in mice widiout linker histone Hit. Histochem Cell Biol 113 433-442 Drabent B, Benavente R, Hoyer-Fender S (2003) Histone Hit is not replaced by Hl.l or H1.2 in pachytene spermatocytes or spermatids of Hit-deficient mice. Cytogenet Genome Res 103 307—313 Ehrenhofer-Murray AE (2004) Chromatin dynamics at DNA replication, transcription and repair. Eur J Biochem 271 2335-2349... 

Studies over the last 10 years clearly demonstrate the importance of histone variants in modifying nucleosome structure and function. They play specialized roles in diverse chromatin functions including transcriptional regulation, DNA repair, chromosome segregation, spermatogenesis, and histone replacement. 

In contrast to these findings in rats are observations made in prepubertal mice that testicular growth and development were not affected by 40 or 48 mg/kg of 1,3-DNB (Evenson et al. 1989a). In pubertal and adult mice, however, abnormal spermatogenesis and an increase in chromatin structure abnormality were apparent after a single dose of 48 mg/kg 1,3-DNB (Evenson et al. 

Sassone-Corsi P 2002 Unique chromatin remodeling and transcriptional regulation in spermatogenesis. Science 296 2176-2178... 

Isolation of Sperm Heads and/or Cell Nucleus Fraction or Chromatin from Fish Testes during Spermatogenesis... 

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