Light-Scattering Spectrometry

R. Trones, Development of Packed Capillary High Temperature Liquid Chromatography Utilizing Light Scattering and Inductively Coupled Plasma Mass Spectrometry Detection, PhD. Thesis, University of Oslo (1999). [Pg.749]

PyMS Pyrolysis mass spectrometry SALS Small-angle light scattering... [Pg.759]

As a result of advances in detection technology, newer HPLC detection techniques may be utilized. For example, evaporative light-scattering detection and refractive index detection may be used to quantify impurities with poor or no UV chromophore. Conductivity detection may also be used. In some cases, when no chromophore is present, chemical derivatization may be used to add a chromophore. Increasingly, tandem techniques such as liquid chromatography mass spectrometry (LC-MS) and GC-MS are utilized for impurity characterization. The highly selective nature of LC-MS ensures that few impurities are undetected. [Pg.12]

Although UV detection is most commonly used in the quahty control of drug substances, other detectors such as fluorescence, electrochemical, near infrared, refractive index, evaporative light scattering, or mass spectrometry may be used as appropriate. [Pg.13]

As noted earlier, certain techniques such as colligative methods, light-scattering photometry, special mass spectrometry (MS) techniques, and ultracentrifugation allow the calculation of specific or absolute molecular weights. Under certain conditions some of these also allow the calculation of the MWD. [Pg.59]

Absolute methods end group analysis, membrane osmometry, vapor pressure osmometry, static light scattering, mass spectrometry, sedimentation measurements. [Pg.73]

Absolute methods provide the molecular weight and the degree of polymerization without any calibration. Their calculation from the experimental data requires only universal constants such as the gas constant and Avogadro s number, apart from readily determinable physical properties such as density, refractive index, etc. The most important methods in use today are mass spectrometry, osmometry, light scattering, and - to some extent - sedimentation and diffusion measurements. Also, some chemical and spectroscopic methods (determination of end-groups) are important because of their relative simplicity. [Pg.92]

United State Pharmacopoeia, USP 24, Chapter (851), Spectrometry and Light-Scattering, 2000. [Pg.172]

EI/MS electron impact/mass spectrometry ELSD evaporative light-scattering detector EM expressible moisture EPA (U.S.) Environmental Protection... [Pg.1307]