Sparfloxacin Digoxin

The quinolone antimicrobial drugs gemifloxacin, levo-floxacin, and sparfloxacin do not interact with digoxin. 

The interaction of sparfloxacin with digoxin, both at steady state, has been studied in a double-blind, placebo-... 

Johnson RD, Dorr MB, Hunt TL, Conway S, Talbot GH. Pharmacokinetic interaction of sparfloxacin and digoxin. Clin Ther 1999 21(2) 368-79. 

Johnson R, Wilson J, Talbot G. The effect of sparfloxacin on the steady-state pharmacokinetics of digoxin in healthy male volunteers. Pharm Res 1994 ll(Suppl) 429. 

Clinically important, potentially hazardous interactions with abarelix, acenocoumarol, amisulpride, amprenavir, anisindione, anticoagulants, arsenic, astemizole, carbimazole, celiprolol, ciprofloxacin, dabigatran, degarelix, dicumarol, digoxin, diltiazem, enoxacin, fentanyl, fosamprenavir, gatifloxacin, grapefruit juice, lomefloxacin, methotrexate, moxifloxacin, nilotinib, norfloxacin, ofloxacin, oxprenolol, quinidine, quinolones, rifabutin, rifampin, rifapentine, ritonavir, simvastatin, sparfloxacin, sulpiride, tacrolimus, tipranavir, verapamil, warfarin, zuclopenthixol... 

Clinically important, potentially hazardous interactions with alfentanil, aminophylline, amisulpride, amoxicillin, ampicillin, anticonvulsants, astemizole, atorvastatin, benzodiazepines, bromocriptine, buprenorphine, bupropion, carbamazepine, cilostazol, ciprofloxacin, cisapride, clindamycin, colchicine, cyclosporine, dasatinib, digoxin, dihydroergotamine, diltiazem, disopyramide, enoxacin, eplerenone, ergotamine, eszopiclone, everolimus, fluconazole, fluoxetine, fluvastatin, gatifloxacin, HMG-CoA reductase inhibitors, imatinib, itraconazole, ketoconazole, lomefloxacin, lorazepam, lovastatin, methadone, methylprednisolone, methysergide, midazolam, mizolastine, moxifloxacin, nitrazepam, norfloxacin, ofloxacin, paroxetine, pimozide, pravastatin, quinolones, ranolazine, repaglinide, rupatadine, sertraline, sildenafil, simvastatin, sparfloxacin, sulpiride, tacrolimus, terfenadine, triazolam, troleandomycin, vardenafil, verapamil, vinblastine, warfarin, zaleplon, zolpidem, zuclopenthixol... 

Levofloxacin, gemifloxacin, moxifloxacin and sparfloxacin do not affect the pharmacokinetics of digoxin. Similarly moxifloxacin does not interact with beta-acetyidigoxin. Gatifloxacin may cause small increases in digoxin levels, which are probably not clinically significant. The effects of garenoxacin are unclear. 

Sparfloxacin, 400 mg as a loading dose, followed by 200 mg daily for 9 days did not affect the pharmacokinetics of digoxin (Lanoxicaps) 300 mierograms daily in 24 healthy subjects. ... 

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