Sources of Chemokines in the Asthmatic Lung

Chemokines can be produced from nearly every cell population within the asthmatic airway, including mast cells, airway epithelial cells, and alveolar macrophages (8,10) (Table 1). Because these cells are resident, they have immediate influence on the environment of the airway and surrounding lung tissue. The initial allergen challenge activates a classic IgE-mediated mast cell degranulation response. The activation of mast cells induces the immediate release of acute mediators, such as histamine, seratonin, or others, that are made and stored in 

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