Sotalol applications

Badaloni, E. et al., Enantioselective liquid chromatographic-electrospray mass spectrometric assay of fS-adrenergic blockers application to a pharmacokinetic smdy of sotalol in human plasma, J. Chromatogr. B, 796, 45, 2003. 

More hydrophilic /3-blockers, such as atenolol, bisoprolol, celiprolol, pindolol and sotalol are predominantly eliminated via the kidney. In elderly patients this may require adaptation of the dosage. Most of the shorter acting /3-blockers are available as slow release preparations. Accordingly, when used as antihypertensives /3-blockers are usually administered once daily. For other applications such as angina pectoris a twice daily dosage may be required. 

Sallustio, B.C. Morris, R.G. Horowitz, J.D. High-performance liquid chromatographic determination of sotalol in plasma. I. Application to the disposition of sotalol enantiomers in humans. J.Chromatogr., 1992, 576, 321-327 [atenolol is IS extracted sotalol derivatization chiral achiral fluorescence detection UV detection plasma SPE]... 

C Lu, Z Luo, L Huang, X Li. The Ru-catalyzed enantioselec-tive preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (5)-sotalol. Tetrahedron Asymm. 2011 22(7) 722-727. 

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