Sorption profile

Nonspecific hydration, or hydration of the lattice without first-order phase transitions, also must be considered. Cox et al. [40] reported the moisture uptake profile of cromolyn sodium, and the related effects on the physical properties of this substance. Although up to nine molecules of water per molecule of cromolyn sodium are sorbed into the crystalline lattice at 90% relative humidity, the sorption profile does not show any sharp plateaus corresponding to fixed hydrates. Rather, the uptake profile exhibits a gradual increase in moisture content as relative humidity increases, which results in... 

Fig. 1.69.2. Moisture sorption profiles of anhydrous lactose (1), mannitol (2), trehalose (3) and sucrose (4). Top before and bottom after lyophilization (% weight change from the data in Table 1.10.4) at different relative humidity (RH) changes over 50-60 h. Before lyophilization 1, lactose — 1.1 RH 10%, 1.2 RH 60% 2, mannitol 3, trehalose - 3.1 RH 10%,...

Fig. 1.69.3. Moisture sorption profiles of dextran and povidone % weight change from the data in Table 1.10.4 (Figure 2 from [1.152])...

Malamataris, S. Dimitriou, A. Moisture sorption profiles and tensile strength of tableted phenobarbitone formulations. J. Pharm. Pharmacol. 1990, 42, 158-163. 

Samples of each polymer were equilibrated at different relative humidities by storage over saturated salt solutions in desiccators. The equilibrated samples were then examined using FT Raman spectroscopy and differential scanning calorimetry (DSC). Gravimetry was used to assess the water vapor sorption profile. Chemometric analysis of spectroscopic data was performed using a commercial software package. Unscrambler (Camo.). 

Table 28 reports the maximum swelling coefficient Qmail, the time needed to reach this equilibrium state tmax, and the constants k and n that characterize the water sorption profiles according to the equation [166] ... 

Figure 54 illustrates the way by which Eq. 16 allows the determination of the complete concentration dependence of the diffusivity from a single transient sorption profile [98]. 

Figure 7.1.11. Sorption profile of 1-butanol in cyclic olefin copofymer at 23 C. [Data from M Limam,...

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