Sone - Prednisone

The use of glucocorticoids for tuberculous meningitis remains controversial. The administration of steroids such as oral prednisone, 60 to 80 mg/ day (1 to 2 mg/kg/day in children), or 0.2 mg/kg/day of IV dexametha-sone, tapered over 4 to 8 weeks, improves neurologic sequelae and survival in adults and decrease mortality, long-term neurologic complications, and permanent sequelae in children. 

Glucocorticoids -sone or -olone Cortisone, dexamethasone, prednisone, prednisolone, triamcinolone Anti-inflammatory (16, 29), immunosuppressants [37]... 

Prednisone [PRED ni sone] is a potent synthetic anti-inflammatory corticosteroid with less mineralocorticoid activity than cortisol (see p. 272). The use of this compound in the treatment of lymphomas arose when it was observed that patients with Cushing s syndrome (a syndrome associated with hypersecretion of cortisol) have lymphocytopenia and decreased lymphoid mass. These result from corticosteroid action on lymphocyte formation and distribution, that is, movement of these cells from the circulation to lymphoid tissue. 

Although, as shown in Table 2.3-K. cortisone and prednisone are not active topically, mo.st other gtuccxronicoids arc active. Some compounds, such as clobetasol and bciaiiiclhu-sone dipropionale. have striking activity topically. Skin absorption is favored by increased lipid solubility of the drug. 

Prednisone, USP. Prednisone. J -cortisone. 17,21-dihy-draxypregna-l.4-dicnc-3,l l.2()-trionc. has systemic activity very similar to that of prednisolone, and becaase of its lower salt-retention activity, it is often preferred over cortisone or hydrocortisone. Predni.sone must be reduced in vivo to prednisolone to provide the active glucocorticoid. 

Low-dose corticosteroids (prednisone, prednisolone, or dexametha-sone) are indicated in patients with adrenal hyperandrogenism or acne fulminans. 

Systemic corticosteroids can increase the loss of potassium, particularly those that are naturally occurring (cortisone, deoxycortone, hydrocortisone) whereas the synthetic derivatives (betamethasone, dexametha-sone, methylprednisolone, prednisolone, prednisone, triamcinolone) have much less mineralocorticoid activity. There is therefore the possibility of potassium depletion, particularly when corticosteroids are used long-term, which may increase the risk of digitalis toxicity. These corticosteroids also cause sodium and water retention, resulting in oedema and hypertension, which can lead to cardiac failure in some individuals. 

Proprietary Names Deltasone , Deltacorti-sone , Deltadehydrocortisone , Orasone , Prednisone and several others in the USA and other countries... 

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