Some Inducible Enzymes of the Liver

The inducible enzymes are listed in Table II. The data are fragmentary but already indicate that several component enzymes are induced in four major systems the heme, microsomal oxygenase, gluconeogenic enzymes, and the direct glucose oxidation systems. The inducible systems show several similarities. (1) The inducible enzymes are not present in the neonate they make their appearance only at birth or a short time after. (2) They interact with one another. For example, 

Fasting and the Increased Synthesis of Certain iNDuaBLE Liver Enzymes 

Inducers Enzyme system affected Enzymes increased 

5 8-H steroids, phenobarbital, drugs Benzpyrene, Microsomal oxygenase Cytochrome P450, NADPH-cyt c reductase Cytochrome P448 

Glucocorticoids Gluconeogenic Examples GIucose-6-phos-phatase, fructose-1,6-diphosphatase, PEP-carboxykinase, tyrosine amino transferase 

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