Solvent-based electrospinning

Hamori, M., Yoshimatsu, S., Hukuchi, Y., Shimizu, Y, Fukushima, K., Sugioka, N., Nishimura, A., and Shibata, N. (2014) Preparation and pharmaceutical evaluation of nano-fiber matrix supported drug delivery system using the solvent-based electrospinning method. Int J. Pharm., 464, 243-251. 

Electrospinning of PLA and copolymers [12] and the PLA stereocomplex [145,146] has been used to prepare nanofibres or nanomats. Similar to the effect of pores on the mechanical properties of PLA-based materials, the formation of nanomats effectively lowers the E and elevates the 8b value. The morphology of the fibres and nanomats and the mechanical properties are affected by the applied voltage, the effluent rate and concentration of the solution, the type of solvent and so on (Figure 8.12 [147]). 

In order to prepare PLA nanocomposites with highly dispersed cellulose nanocrystals and porous PLA-based scaffolds with enhanced mechanical properties and thermal stability, CNCs have been incorporated into PLA fibres by electrospinning method. Fibrous biocomposite mats consisting of PLA and CNCs have been electrospun from solvent or solvent mixtures such as l,l,l,3,3,3-hexafluoro-2-propanol (HFP), DMF/chloro-form and DMF/tetrahydrofuran (THF). The electrospun PLA/CNCs bionanocomposites have demonstrated rapid in vitro biodegradability and cytocompatible properties, and could be potentially suitable in tissue engineering. ... 

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