Solution phase synthesis oligosaccharide libraries

In the synthesis of diverse oligosaccharide libraries, a conventional SPOS methodology would involve laborious solution-phase preparation of many building blocks and that number would increase if increased diversity of the library is to be obtained. To develop a versatile and practical approach, it is necessary to reduce the number of building blocks ideally... 

The advantage of solution phase approaches for constructing combinatorial libraries is the direct translation of known solution chemistry to library synthesis, versus the need to reengineer these chemistries to be compatible with the solid phase environment. Three approaches have been reported for generating solution phase oligosaccharide libraries [27-30]. The first reported strategy attempted to address one of the inherent challenges and costs associated with... 

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