Oligosaccharide synthesis solution-phase

These results demonstrate that O-glycosyl trichloroacetimidate-based oligosaccharide synthesis on solid support may eventually become a valuable alternative to solution-phase synthesis because useful experience is available for the selection of the polymer support and choice of the linker system and the glycosyl donor. Further standardization of the building blocks and the protective group pattern will finally provide the yields and the anomeric control in order to successfully plan automated syntheses of oligosaccharides also in a combinatorial manner. 

Polyethyleneglycol oo-Monomethylether (MPEG)-Supported Solution-Phase Synthesis of Oligosaccharides... 

MPEG)-SUPPORTED SOLUTION-PHASE SYNTHESIS OF OLIGOSACCHARIDES... 

In the synthesis of diverse oligosaccharide libraries, a conventional SPOS methodology would involve laborious solution-phase preparation of many building blocks and that number would increase if increased diversity of the library is to be obtained. To develop a versatile and practical approach, it is necessary to reduce the number of building blocks ideally... 

Solution-phase oligosaccharide synthesis remains a slow process due to the need for iterative coupling and deprotection steps, with purification at each step along the way. To alleviate the need for repetitive purification events, solid-phase techniques have been developed.29,30 In solid-phase... 

Scheme 4.19 Solid-phase oligosaccharide synthesis with glycosyl donors in solution.

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