Oligosaccharide Diversity

Among structurally diverse glycoprotein oligosaccharides, those containing repeating N-acetyl-lactosamine structures attract much attention in connection with various biological events, most notably as onco-differentiation markers. 

A linker originally designed for solid-phase synthesis of peptides is the backbone amide linker (11) (BAL), this anchoring approach has now been extended to the combinatorial synthesis of diverse amide [31], hydroxamate [32], oligosaccharide [33] and heterocyclic small molecule libraries [34-36]. 

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