Solubilizing agents effect

Anionic surfactants (SDS and deoxycholate) are more effective solubilizing agents at higher concentration than nonionic surfactants (Lubrol, Triton)... 

In this equation, the value of (Red) is a function of the nature of the reductant, its solubility, the crystallinity of solid phases containing it, effects of solubilizing agents, transport limitations, and other factors. Likewise the value of (Ox) is a function of various factors. As discussed in the previous chapter, most redox reactions are very slow and the prevailing conditions are therefore sensitive to catalysis. Three types of catalysis are involved ... 

For oral liquids, taste masking becomes essential. The effects of solubilizing agents such as complexing agents and cosolvents on taste need to be evaluated. 

Numerous phase I clinical trials have already been conducted in the United States in which, using various protocols 156-160), the effects of taxol on solid tumors and on adult leukemia [a single study (767)] were evaluated. These studies have permitted determination of the doses (200-250 mg/m ) and the protocol (30 mg/m /day preceded by treatment with glucocorticoids and antihistamines) recommended for phase II evaluation, keeping in mind the main side effects caused by the solubilizing agent as well as leukopenic and neurotoxic effects. These phase II trials are currently underway, and only the results of one study (on a renal carcinoma) are presently available (762). It should be noted that one of the main obstacles to more rapid development of therapeutic uses of taxol is the very limited quantities of this drug available, for reasons already discussed. 

---