Solubilization with block co-polymeric surfactants

So far in this chapter we have attempted to survey solubilization of pharmaceutical products by drug class. Here we diverge to discuss solubilization by a class of surfactant. For reasons of toxicity many ionic surfactants are excluded from serious contention as solubilizing agents for use in medicines. Not all non- 

Poloxamer Pluronic Molecular m+ Percent Molecular Total 

Nuclear magnetic resonance has been used [248] to study the interaction of poloxamer F68 and phenol. Starting with low phenol concentrations, up to 2%, in a 10% aqueous poloxamer F68 solution, it was reported that the phenol was associated mainly with the polyoxypropylene chain. However, as the ratio of phenol to poloxamer increased, it appeared that the polyoxypropylene chain became saturated with phenol and relatively more phenol entered the polyoxyethylene chain. 

A chlorhexidine gluconate-poloxamer 187 solution has been developed as an antiseptic skin cleansing formulation [249]. This contains 25% poloxamer 187, chosen to produce the greatest foaming capacity and also because the poloxamers as a class interfere with the activity of the chlorhexidine less than other non- 

Marked increases in the dissolution rate of digitoxin and digoxin has been achieved by dispersing the drugs in solid poloxamer 188 (Pluronic F68) as a carrier [251] (see Fig. 6.34). Poloxamer 188, in concentrations equivalent to that in the digoxin co-precipitates studied, increased the solubility of the digoxin as shown in Table 6.29 in which results are compared with the effects of deoxycholic 

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