Solubilities of organic liquids

Hansch, C., Quinlan, J. E., Lawrence, G. L. The linear free-energy relationship between partition coefficients and the aqueous solubility of organic liquids. 

Let us consider the temperature dependence of the mole fraction solubility of organic liquids. Since xs /xiL = x (xlL = 1) represents the partitioning constant between the aqueous phase and the pure liquid, for a narrow temperature range, its temperature dependence is given by (Section 3.4) ... 

Hydrogen-bond formation is of importance also for various other properties of substances, such as the solubility of organic liquids in water and other solvents, melting points of substances under water,1 viscosity of liquids,14 second virial coefficient of gases,18 choice of crystal structure, cleavage and hardness of crystals, infrared absorption spectra, and proton magnetic resonance. Some of these are discussed in the following sections of this chapter. 

An excellent historical review of LFERs is available (255). An example of an LFER study, relating partition coefficients to aqueous solubility of organic liquids, may be found in Reference 256. 

Hansch, C., J.E. Quinlan, and G.L. Lawrence. 1968. The Linear Free Energy Relationships Between Partition Coefficients and the Aqueous Solubility of Organic Liquids. J. Org. Chem. 33 347-350. 

Schwarz, F.P, Miller, J. (1980) Determination of the aqueous solubilities of organic liquids in water by elution chromatography. Anal. Chem. 52, 2161-2164. 

SOLUBILITY OF ORGANIC LIQUIDS IN WATER AND WATER IN ORGANIC LIQUIDS... 

Table 11.3 Approximate solubilities of organic liquids in water, and of water in organic liquids at 25°C...

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