Solifenacin Warfarin

Clinically important, potentially hazardous interactions with alprazolam, aprepitant, astemizole, atorvastatin, benzodiazepines, carbamazepine, chlordiazepoxide, cilostazol, clonazepam, clorazepate, colchicine, conivaptan, cyclosporine, dabigatran, dasatinib, diazepam, digoxin, dihydroergotamine, disopyramide, ergot alkaloids, fesoterodine, fluoxetine, flurazepam, fluvastatin, HMG-CoA reductase inhibitors, imatinib, ixabepilone, lapatinib, lopinavir, lorazepam, lovastatin, methylprednisolone, methysergide, midazolam, nilotinib, oxazepam, paroxetine, pimozide, pravastatin, prednisone, quazepam, repaglinide, rimonabant, rivaroxaban, sertraline, silodosin, simvastatin, solifenacin, temazepam, temsirolimus, tolvaptan, trabectedin, triazolam, warfarin, zidovudine... 

Clinically important, potentially hazardous interactions with alcohol, anticoagulants, antihistamines, betamethasone, brompheniramine, buclizine, buprenorphine, chlorpheniramine, darunavir, dasatinib, delavirdine, dexamethasone, dicumarol, ethanolamine, fesoterodine, fluconazole, flunisolide, fosamprenavir, hydrocortisone, imatinib, influenza vaccines, lacosamide, lapatinib, lopinavir, meperidine, methylprednisolone, midazolam, nilotinib, piracetam, pizotifen, prednisolone, prednisone, rivaroxaban, rufinamide, solifenacin, telithromycin, temsirolimus, teniposide, trabectedin, triamcinolone, warfarin... 

Clinically important, potentially hazardous interactions with amiodarone, amprenavir, anisindione, antacids, anticoagulants, aprepitant, atazanavir, atovaquone, beclomethasone, buprenorphine, corticosteroids, cortisone, cyclosporine, cyproterone, dabigatran, dapsone, darunavir, delavirdine, dexamethasone, dicumarol, digoxin, eszopiclone, flunisolide, fosamprenavir, gadoxetate, gestrinone, halothane, imatinib, isoniazid, itraconazole, ketoconazole, lapatinib, lorcainide, methylprednisolone, midazolam, nelfinavir, nifedipine, oral contraceptives, phenylbutazone, prednisone, protease inhibitors, pyrazinamide, ramelteon, ritonavir, saquinavir, solifenacin, sunitinib, tacrolimus, telithromycin, temsirolimus, tipranavir, tolvaptan, trabectedin, triamcinolone, triazolam, voriconazole, warfarin, zaleplon... 

Clinically important, potentially hazardous interactions with amiodarone, anisindione, anticoagulants, corticosteroids, cyclosporine, dicumarol, indinavir, ritonavir, solifenacin, tacrolimus, warfarin... 

Solifenacin did not alter the pharmacokinetics or effect of warfarin. Similarly, darifenacin did not alter the prothrombin time in response to warfarin. 

In a placebo-controlled, crossover study in healthy subjects, solifenacin 10 mg daily for 10 days had no effect on the pharmacokinetics of 5- orR-warfarin after a single 25-mg dose of warfarin was given on day 10. In addition, solifenacin did not alter the prothrombin time. ... 

Smulders RA, Kuipers ME, Krauwinkel WJJ. Multiple doses of the antimuscarinic agent solifenacin do not affect the pharmacodynamics or pharmacokinetics of warfarin or the steady-state pharmacokinetics of digoxin in healthy subjects. BrJ Clin Pharmacol (2006) 62,210-17. 

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