Solid-state analysis organic matter

The goal of early stage solid-state analysis is the determination of the tendency of a compound to crystallize into different forms. It may have many forms like sulfathiazole with at least four polymorphs [6] or methylestradiol with one anhydrous form, two hydrated forms and at least two solvated forms [4]. This information guides the course of the future studies. If only one pharmaceutically significant form exists, then the subsequent studies should be straightforward and relatively rapid. If many forms exist, choosing the optimal form for development may require extensive time and study. It is useful to operate on the principle that all organic compounds crystallize in different forms and that the only questions are How many and How important McCrone [7] put the matter this way ... 

Cao X, Oik D, Chappell M, Cambardella CA, Miller LF, Mao J. Solid-state NMR analysis of soil organic matter fractions from integrated physical-chemical extraction. Soil Sci. Soc. Am. J. 2011 75 1374-1384. 

Simpson, M. J., and Preston, C. M. (2007). Soil organic matter analysis by solid-state 13C nuclear magnetic resonance spectroscopy. In Soil Sampling and Methods of Analysis. CRC Press, Boca Raton, FL, pp. 195-200. 

Smernik, R. J., and Oades, J. M. (2003). Spin accounting and RESTORE—two new methods to improve quantitation in solid-state 13C NMR analysis of soil organic matter. Eur. J. Soil Sci. 54,103-116. 

A method has been developed to demineralize sediment trap material and marine sediments containing labile organic matter, in preparation for solid-state CPMAS NMR analysis. ... 

Guggenheim EA (1945) The principle of corresponding states. J Chem Phys 13 253-265 Hantal G, Darvas M, Partay LB, Horvai G, Jedlovszky P (2010) Molecular level properties of the free water surface and different organic Uquid/water interfaces, as seen from ITIM analysis of computer simulation results. J Phys Condens Matter 22(28) 284112-1/14 Henderson MA (2002) The interaction of water with solid surfaces fundamental aspects revisited. Surf Sci Rep 46 1-308... 

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