Sodium intestinal absorption

Treatment. Treatment of poisoning from soluble barium salts may be preventive or curative (47,51). Preventive treatment involves inhibition of intestinal absorption by administering such soluble sulfates as magnesium or sodium, causing precipitation of barium sulfate in the alimentary tract. 

KREYDIYYEH s I, ABDEL-HASAN BAYDOUN E, CHURUKiAN z M (1994) Tea exfract inhibits intestinal absorption of glucose and sodium in rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 108 359-65. 

In extensive studies of the effect of fluoride In patients with osteoporosis carried out In this Research Unit, a therapeutic dally dose of 45 mg fluoride per day was used as sodium fluoride. The main effect of fluoride on calcium metabolism was a decrease of the urinary calcium, while the fecal calcium did not change and the calcium balance also remained unchanged. Also, the Intestinal absorption of calcium remained unchanged during the high fluoride Intake (Table I), The decrease In urinary calcium, Induced by sodium fluoride, may be due to decreased bone resorption, a very desirable effect for patients with osteoporosis. 

Sancho-Chust, V., Bengochea, M., Fabra-Campos, S., Casabo, V.G., Martinez-Camara, M.J., and Martin-Villodre, A., Experimental studies on the influence of surfactants on intestinal absorption of drugs. Cefadroxil as model drug and sodium lauryl sulfate as model surfactant studies in rat duodenum, Arzneim.-Forsch./Drug Res., 45, 1013, 1995. 

Mechanism of Action A nonabsorbable compound that alters urinary composition of calcium, magnesium, phosphate, and oxalate. Calcium binds to cellulose sodium phosphate, thus preventing intestinal absorption of it. Therapeutic Effect Prevents the formation of kidney stones. 

Morishita, M., et al. 1993. Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin. Biol Pharm Bull 16 68. 

Raoof, A.A., et al. 2002. Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs. Eur J Pharm Sci 17 131. 

Tomita M, Hayashi M, Awazu S (1995) Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells. J Pharmacol Exp Ther 272 739-743 Uchiyama T, Yamamoto A, Hatano H, Fujita T, Muranishi S (1996) Effectiveness toxicity screening of various absorption enhancers in the large intestine intestinal absorption of phenol red and protein and phospholipid release from the intestinal membrane. Biol Pharm Bull 19 1618-1621... 

Wu S-Y, Robinson JR (1999) Transcellular lipophilic complex-enhanced intestinal absorption of human growth hormone. Pharm Res 16 1266-1272 Yamashita S, Saitoh H, Nakanishi K, Masada M, Nadai T, Kimura T (1987) Effects of diclofenac sodium and disodium ethylenediaminetetraacetate on electrical parameters of the mucosal membrane and their relation to the permeability enhancing effects in the rat jejunum. J Pharm Pharmacol 39 621-626... 

The intestinal absorption of pantothenic acid is by use of the same sodium-dependent carrier as biotin and lipoic acid (Section 11.1). The carrier is found throughout the intestinal tract, and therefore pantothenic acid synthesized by intestinal bacteria (Section 12.2.4) will, like biotin, be available for absorption (Said et al., 1998 Chatterjee et al., 1999 Ramaswamy, 1999 Said, 1999 Prasad... 

Vitamin C Ascorbic acid is the most important redox substance of cell metabolism. The body content probably amounts to about 2-5 g, the major part being stored in the liver and muscles. Intestinal absorption (80-90%) is an active, sodium-dependent process. The transport of ascorbic acid in the blood probably takes place as an ascorbic acid-albumin complex. Cellular uptake is stimulated by insulin. 

An oral formula suitable for the correction of a variety of diarrheal fluid losses has been recommended by the World Health Organization (WHO). It consists of 90 mM Na, 20 mA1 K, 00 mM Cl, 30 mM HCOj, and HO mM glucose. The glucose aids in intestinal absorption of sodium ions, because glucose transport is mediated by the Ma-glucosc cotransporter. Only low levels of sugar are used in oral replace-... 

Intestinal absorption of salt and water is stimulated by angiotensin II and aldosterone. Angiotensin II stimulates the absorption of Na by the jejunum and ileum. Nerves leading from the brain to the gut may also control sodium absorption by the gut. Angiotensin II in the brain may play a part in this mechanism. Aldosterone seems to have no effect on salt absorption by the small intestines. The kidney is controlled by the nervous system. The nervous control of salt absorption by the kidney seems to play only a minor role in salt balance. Aldosterone stimulates the colon to absorb Na. Plasma angiotensin II is not thought to have a direct effect on salt absorption by the colon. The material described here is outlined in Figure 10.11. 

Frawley JP. Studies on the gastro-intestinal absorption of purified sodium carboxymethylcellulose. Food Cosmet Toxicol 1964 2 539-543. 

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