Sodium glycolate thermal stability

High temperatures can break native S-S bonds and form new S-S bonds which can lock the protein into a denatured eonfiguration [89]. Low pH, sodium dodecyl sulfate. Tween 80, chaotropie salts, and exogenous proteins have been used to protect proteins from thermal inaetivation [90]. Ethylene glycol at 30-50% was used to protect the antiviral activity of P-interferon preparations [91]. Human serum albumin was used in recombinant human interferon-Psei-n which resulted in increased thermal stability [62]. Water-soluble polysaeeharides sueh as dextrans and amylose [92], as well as point-specific (site-directed) mutagenesis [93] have also been used to increase thermal stability of therapeutie proteins and peptides. 

Wong et al. [41] showed that sodium montmorillonite imparted a better thermal stability to polyvinylidene difluoride-polyethylene (PE) glycol polymers than did organic montmorillonite. They showed that ethyl-3-methylimidazolium tetrafluoro-borate-functionalized montmorillonite greatly enhanced the thermal stability of the polymer. Liu et al. [42] studied the effect of various organoclays on the heat stability of poly trimethylene terephthalate. 

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