Sodium bicarbonate dosage

When electrolytes are administered parenterally, the dosage is expressed in milliequivalents (mEq), for example, calcium gluconate 7 mEq IV When administered orally, sodium bicarbonate, calcium, and magnesium dosages are expressed in milligrams (mg). Potassium liquids and effervescent tablet dosses are expressed in milliequivalents capsule or tablet dosses may be expressed as milliequivalents or milligrams. 

Sodium bicarbonate administration for cardiac arrest is controversial because there are few clinical data supporting its use, and it may have some detrimental effects. Sodium bicarbonate can be used in special circumstances (i.e., underlying metabolic acidosis, hyperkalemia, salicylate overdose, or tricyclic antidepressant overdose). The dosage should be guided by laboratory analysis if possible. 

Tromethamine, a highly alkaline solution, is a sodium-free organic amine that acts as a proton acceptor to prevent or correct acidosis. However, no evidence exists that tromethamine is beneficial or more efficacious than sodium bicarbonate. The usual empiric dosage for tromethamine is 1 to 5 mmol/kg administered IV over 1 hour and an individualized dose can be calculated as follows ... 

Cinchophen has a tendency to produce severe liver damage and should be used with caution. Dosage, 300 to 600 mg with 2 to 5g sodium bicarbonate (baking soda) and a pint of water. 

Antacids Indometacin ( other NSAIDs) Variable effects of different formulations aluminium-containing antacids reduce the rate and extent of absorption of indometacin sodium bicarbonate increases the rate and extent of absorption of indometacin No action required, unless a marked reduction in absorption results in a poor response to the NSAID, in which case dosages may need to be increased or the antacid withdrawn... 

Recently, sodium bicarbonate has been used as a gasforming agent in alginate raft systems and in floating, controlled-release oral dosage forms of furosemide and cisapride. Tablet formulations containing sodium bicarbonate have been shown to increase the absorption of paracetamol, and improve the stability of levothyroxine. ... 

It is considered to be one of the choicest drug specifically for salicylate medieation and is usually administered with either sodium bicarbonate to minimise effeetively the gastric distress or as enteric-coated dosage forms. However, the usage of NaHCOj is not advisable as it is found to retard the plasma levels of salicylate and enhances the elimination of free salicylate in the urine. 

A 35-year-old man, started on lithium earbonate 250 mg four times a day, had a serum-lithium level of 0.5 mmol/L by the following morning. When the dosage fiequency was progressively increased to five, and later six times a day, his serum-lithium levels did not exceed 0.6 mmol/L because, unknown to his doctor, he was also taking sodium bicarbonate. 

The patient s wife said he had been taking Soda Bic for years but since he started on lithium he had been shovelling it in. When the sodium bicarbonate was stopped, relatively stable serum-lithium levels of 0.8 mmol/L were achieved on the initial dosage of lithium carbonate. ... 

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