Sodium barbiturates

Barbituric acids as their name implies are weakly acidic and are converted to then-sodium salts (sodium barbiturates) m aqueous sodium hydroxide Sometimes the drug is dispensed m its neutral form sometimes the sodium salt is used The salt is designated by appending the word sodium to the name of the barbituric acid—pentobarbital sodium for example... 

Similarly, the reaction with bromine yields the corresponding 5-bromo derivatives, which are suitable substrates for nucleophilic displacement or dehydrohalogenation reactions. Typical nucleophiles (Nu) are H2O, NH, RNH2, and sodium barbiturates ... 

The proplnts described above are in the realm of prior art and depict those NC proplnts with low smoke potential that are used primarily as gun proplnts. Recent research and development work has been concentrated on creating both gun proplnts and rocket proplnts with reduced smoke output in order to foil countermeasures. Lavitt (Ref 76) found that the concurrent use of optimum proportions of lead stearate and sodium barbiturate in double-base proplnts resulted in a marked reduction in smoke output. This was attributed to the synergistic interaction of the two salts to produce more complete oxidation of the exhaust products. The importance of using the optimum ratio of the two catalysts is demonstrated by the higher smoke values shown in Table 4 for Propellants 105, 106 and 107, when compared to other... 

When 10.0 mg of sodium barbiturate dissolve in 250 mL of solution, the resulting pH is 7.71. The molar mass of sodium barbiturate is 150 g-mol-1. Determine (a) the percentage protonation of barbiturate ions (b) the of barbituric acid. 

For hemoglobin Barbital 8.5 0.05 5.0 g Sodium barbiturate 3.33 g Hydrated sodium acetate 1.0 g Hydrated copper sulfate 34.2 ml 0.1 A Sulfuric acid 250-300 volts 16-20 (M26)... 

Ionophoresis of the buffer salts. When considering evaporation (Section 1.1.1.1) mention was made of sodium determination in eluates of the strip after the run. Measurements of potential on the strip have confirmed the presence of salt zones (unpublished and P21). When current is applied, the sodium peak due to evaporation moves partially toward the cathode and diminishes at the same time. A second new and unexpected sodium peak appears near the anode (Fig. 16). Determinations of both sodium and barbiturate proved the presence of both ions together on the same spot (P8). Experiments with sodium barbiturate as anodic electrolyte and potassium barbiturate as cathodic electrolyte proved that it is an accumulation of the cation leaving the anodic buffer vessel which causes this new and unexpected peak (Fig. 17). The reason appears to lie in the unequal mobilities of the two ions which tend to occupy a zone from which the faster ion (sodium) needs the same time to reach the cathode as the slower ion (barbiturate) needs to reach the anode (G26, P7). It is, of course, necessary that one anion be discharged at the same moment as one cation. 

After electrophoresis of a sodium barbiturate buffer the sodium was determined. The same result was obtained consistently as given in Fig. 45 which summarizes the mean of the figures of four similar experiments... 

The results of an experiment with simultaneous use of a potassium buffer in one electrode compartment, a lithium buffer on the curtain, and sodium barbiturate buffer in the other electrode compartment are shown in Fig. 46 (P7). The pattern of the different ions can be repeated... 

It has been observed that the sodium barbiturates , in general, exhibit extremely lipophilic property that may cause distinct and rapid chemical incompatibility reactions, such as precipitation, when such compoimds are inadvertently brought in contact with the acid salts of relatively weak basic amines. 

Pollard, M., Luckert, P.H., Promotional Effect of Sodium Barbiturate on Intestinal Tumors Induced in Rats by Dimethyl-hydrazine, J. Natl. Cancer Inst., 1979, 63 1089-1092. 

Sodium barbiturate, as well as a number of other compounds, suppressed the fighting stance of the Cantonese fighting fish, suggesting that this fish is not a suitable animal for the differentiation of tranquillisers [139]. Barbituric acid slightly diminished the effect of 2,4-dinitrophenol on rectal temperatures [140]. 

FIGURE 14.1 Molecular structure of some of the common illicit drugs (top left to right bottom) cocaine, heroin hydrochloride, amphetamine, benzodiazepine derivative, sodium barbiturate, and psilocin. Note that all these are nitrogen bases. 

The reaction between cyanide, sodium isonicotinate and sodium barbiturate has been used for the spectrophotometric determination of cyanide by Nagashima [33]. 

Mutant strains of S. peucetius fed with sodium barbiturates produce biosynthetic anthracyclines having barminomycin structures... 

In the electrophoretic method (391), the electrolyte was 0.025 M sodium barbiturate, 0.05 M sodium acetate, or 0.025 M sodium octoate, with the pH adjusted to 8.6 by means of 0.1 fi hydrochloric acid. The sample solution was applied on Whatman No. 1 paper which had been previously equilibrated with electrolyte. After 30 min at 5°... 

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