Sodium Apazone

Piperacillin sodium Diethyl-d -phenyl propyl) malonate Phenprocoumon Diethylpropyl malonate Apazone... 

The benzotriazine-1-oxide (530) [701] was hydrogenated to the 1,2-dihydrobenzotriazine (531) which reacted with propylmalonyl chloride in the presence of triethylamine (or sodium and diethyl 2-propylmalonate) to give apazone (azapropazone, 532) Scheme 5.125.) [702-704]. Although the dioxopyrazolidine ring and the exocyclic amine group are readily hydrolysed or oxidized, the main metabolite was found to be the 8-hydroxy derivative [705]. Apazone has anti-inflammatory activity comparable to phenylbutazone, mefenamic acid and flufenamic acid. It also shows antinociceptive and weak antipyretic activity [706]. 

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