Sodium amide Vitamin

The elimination is effected by treatment of 16 with an excess of sodium amide in liquid ammonia containing r-BuOH to give vitamin A (17). Again, this protic reagent is crucial for the successful elimination. The content of the (all- )-isomer in the product thus obtained is 67% at best. 

The diacetone-D-glucosyl-3-0-(A A -diethylamido)thiophosphates of the lipid-soluble vitamins D2, D3, and E have been obtained in a one-pot procedure by sequential addition of the vitamin, the sugar, and sulfur to phosphorous acid tris(A,A -diethyl)amide in the presence of catalytic iodine. In the preparation of the 3-[sodium-2-(perfluoroalkyl)ethyl phosphates] 47 of diacetone glucose. 

Vitamin B5 occurs in three biologically active forms in foods [1] pantothenic acid, coenzyme A (CoA), and acyl carrier protein (ACP). Calcium or sodium pantothenate are the forms generally used as supplements in infant formula [4], The total quantification of vitamin B5 requires the release of pantothenic acid from CoA and ACR Since it consists of pantoic acid linked through an amide linkage to p-alanine, chemical hydrolysis cannot be used. The only alternative to free pantothenic acid from CoA is the digestion with a number of enzymes (pepsin, alkaline phosphatase, pantetheinase) nevertheless, this treatment is unable to release the vitamin from ACP [27,28]. For the extraction of free pantothenic acid from milk and calcium pantothenate from infant formula an acidic deproteination is often used, followed by centrifugation and filtration [29,30]. 

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