Smart Polymers Controlled Delivery of Drugs

Environmental stimulus responsive material Responsive material 

Ultrasound Controllable protein release Specialized equipment for controlling the release 

Temperature Ease of incorporation of active moieties Injectability issues under application conditions. Simple manufacturing and formulation 

Mechanical stress Possibility to achieve the drug release Difficulty in controlling the release profile 

Light Ease of controlling the trigger mechanism Low mechanical strength of gel, chance of leaching out of noncovalently attached 

---