Skin inflammation phagocytes

Ultraviolet-induced Skin Inflammation 4.1 Role of Phagocytes... 

The PMN cells include neutrophils, eosinophils, and basophils. Neutrophils make up 60-75% of circulating WBCs and provide the first line of defense against microbes that penetrate the normal barriers of skin. They are extremely efficient phagocytes and are a source of inflammatory cytokines and lipid mediators such as PGs, LTs, and platelet-activating factor. Eosinophils are involved in allergy and provide protection against parasites. Basophils contain vasoactive amines such as histamine, serotonin, and heparin, as well as precursors for PGs and LTs. Release of these pharmacological materials by the basophils is responsible for the anaphylactic reaction. These factors also serve as chemoattractants for neutrophils and eosinophils to sites of inflammation. 

Many flavonoids modify the phagocytic processes of macrophages, the release of oxidant substances from neutrophils and the activation of mast cells. Their interaction with the arachidonic acid metabolism and inhibition of pro-inflammation mediators such as prostaglandins might be responsible for their anti-inflammatory activity. Chamomile exerts a powerful anti-inflammatory action due to its flavonoid content (Ramos et al., 1996). This action is mainly due to apigenin and lutein (Avallone et al., 2000). Traditionally, chamomile has been used in cosmetic products as soothing, anti-irritant and for sensitive skins. 

---