Skin contact with hydrogen bromide

Hydrogen bromide is extremely irritating to the eyes, mucous membranes of the respiratory tract, and skin. Contact may cause bums. Repeated short exposures to concentrations of about 35 ppm can cause irritation to the nose and throat with mucous production and indigestion. Inhalation of higher concentrations can cause pulmonary edema and laryngeal spasm, and can be fatal. Skin contact with the vapor or liquid causes severe tissue irritation and necrosis [2]. 

Irritant dermatitis does not involve an immune response and is typically caused by contact with corrosive substances that exhibit extremes of pH, oxidizing capability, dehydrating action, or tendency to dissolve skin lipids. In extreme cases of exposure, skin cells are destroyed and a permanent scar results. This condition is known as a chemical burn. Exposure to concentrated sulfuric acid, which exhibits extreme acidity, or to concentrated nitric acid, which denatures skin protein, can cause bad chemical bums. The strong oxidant action of 30% hydrogen peroxide likewise causes a chemical bum. Other chemicals causing chemical bums include ammonia, quicklime (CaO), chlorine, ethylene oxide, hydrogen halides, methyl bromide, nitrogen oxides, elemental white phosporous, phenol, alkali metal hydroxides (NaOH, KOH), and toluene diisocyanate. 

Hazards Handle 99% anhydrous hydrazine with care. Never distill it in the presence of air, and keep it out of contact with strong oxidizers. Wear gloves, and use proper ventilation when handling cyanogen bromide. Cyanogen bromide is highly poisonous, and inhalation of vapors, or skin absorption can be fatal toxic effects are similar to hydrogen cyanide. 

Toxicity and health effects Human exposure to hydrogen bromide causes redness, pain, frostbite, and severe burns and blisters on the skin. Eye contact with the liquid causes redness, pain, severe burns, and possible permanent eye damage. It causes nose and throat irritation, watery eyes, bloody nose, nausea, vomiting, chest pain and/or light-headedness, coughing, shortness of breath, fluid in the lungs or pulmonary edema, unconsciousness, low blood pressure, rapid heartbeat, kidney failure, coma, and death. ... 

Boron Iribromide (CAS 10294-33-4) Corrosive decomposed by tissue moisture to hydrogen bromide (see p 140) and boric acid (see p 135). Severe skin and eye burns may result from direct contact. Vapors highly irritating to eyes and respiratory tract. 1 ppm (C) 3 0 2 W Colorless fuming liquid. Reacts with water, fomiing hydrogen bromide and boric acid. Vapor pressure is 40 mm Hg at14°C (57°F). 

Dibromo-3-chioropropane (DBCP [CAS 96-12-8]) Irritant oi eyes and respiratory tract. Has caused sterility (aspermia, oligospermia) in overexposed men. Well absorbed by skin contact and inhalation. A carcinogen in test animals (lARC 2B). OSHACA NIOSH CA Brown liquid with a pungent odor. Combustible. Thermal-breakdown products include hydrogen bromide and hydrogen chloride. No longer used as a pesticide in the US. 

Toxicology LD50 (oral, rat) > 5000 mg/kg, (skin, rabbit) > 2000 mg/kg contact may result in skin, eye irritation nonmutagenic Precaution Incompat. with strong alkalis, may cause hydrolysis and release of bromine treat as burning oil Hazardous Decomp. Prods. Hydrogen bromide, CO,... 

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