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Skin cancer drugs that cause

Toxicities are numerous and include nephrotoxicity, hypertension, hyperglycemia, liver dysfunction, hyperkalemia, altered mental status, seizures, and hirsutism. Cyclosporine causes very little bone marrow toxicity. While an increased incidence of lymphoma and other cancers (Kaposi s sarcoma, skin cancer) have been observed in transplant recipients receiving cyclosporine, other immunosuppressive agents may also predispose recipients to cancer. Some evidence suggests that tumors may arise after cyclosporine treatment because the drug induces TGF-B, which promotes tumor invasion and metastasis. [Pg.1191]

Changes in the optical properties of the skin, such as those caused by a drug vehicle, can result in a greater UV dose to the viable layers of the skin. Data on correlation of latitude, UV exposure, and cancer risk in humans indicate that an increase in UV exposure as small as 20% could result in a fourfold increase in basal-cell carcinoma.16... [Pg.80]

This concern isn t entirely theoretical penicillins, quiescent affinity label as mentioned above, cause allergies (mostly skin rashes and hives) in about 2% of the patients who take them, and even potentially fatal anaphylaxis in a few, and toxicity is believed to proceed through this sort of mechanism. With the current atmosphere about drug safety, it s no wonder that many companies will only consider working on irreversible inhibitors where the benefits clearly outweigh the risks as in the case of cancer, in the context of tool compounds, or perhaps not at all. Had penicillin been discovered today quite a few companies might choose not to develop it. [Pg.286]


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See also in sourсe #XX -- [ Pg.228 ]




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