Skeletal muscle Na+ channels

Hirschberg, B., Rovner, A., Lieberman, M., and Patlak, J. (1996). Transfer of twelve charges is needed to open skeletal muscle Na+ channels./. Gen. Physiol. 106, 1053-1068. 

Horn It is not an obvious feature of the human skeletal muscle Na channel, which is the one that we primarily use. 

Rojas CV, Wang JZ, Schwartz LS, Hoffman EP, Powell BR, Brown RH Jr 1991 A Met-to-Val mutation in the skeletal muscle Na+ channel alpha-subunit in hyperkalaemic periodic paralysis. Nature 354 387—389... 

The extraceUular domain of (33 is critical for modulation of channel gating and voltage-dependence of brain and skeletal muscle Na channels expressed in Xennpus oocytes (Chen Cannon 1995, Makita et al 1996, McCormick et al 1998, 1999). Removal of the intracellular domain of (33, substitution of the intracellular (33 domain with the corresponding domains from either (32 or the structurally related CAM myehn P, or attachment of the (33 extraceUular domain to the plasma membrane via a glycosylphosphatidylinositol anchor aU resulted in... 

Talon, S., De Luca, A., De Beilis, M., Desaphy, J.-F., Lentini, G., etal. (2001) Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na channels enhancing the antimyotonic activity in vivo. Br. J. Pharmacol. 134 1523-1531. 

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