Skeletal connectivities

Sarcomas are tumors of mesenchymal origin, arising in skeletal tissues and extra-skeletal connective tissues including the nerves. They are very rare and mainly effect a younger population. Sarcomas of soft tissues are relatively insensitive to drug treatment and are therefore not discussed in detail in this chapter. A systematic review of fourteen trials of doxorubicin-based adjuvant chemotherapy for the treatment of soft tissue sarcomas involving 1568 patients concluded Doxorubicin-based adjuvant chemotherapy appears to significantly improve time to local and distant recurrence and overall recurrence-free survival in adults with localised resectable soft tissue sarcoma. There is some evidence of a trend towards improved overall survival (see Sarcoma Meta-analysis Collaboration, 1999). 

Figure 3.7. Skeletal two- and three-center bond arrangements possible for CH units of skeletal connectivity k = 3,4,5, or 6 (exo-hydrogens not shown). Bond orders h refer to the mean number of electron pairs per B-C hnk for the bond network in question.

Noden, D. 1983. The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues. Devi. Biol. 96, 144-165. 

Sclerins, Seleroproteins, or Albuminoids.— Insoluble proteins found in the skeletal, connective, and epidermal tissues of animals. They do not occur in plants. Seleroproteins are very stable, and resist acid and alkaline hydrolysis, but ultimately are resolved into amino acids. 

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