Site-limited intermediate, definition

Most polymers are inherently non-toxic and can be sufficiently defined to present no unreasonable risk. Site-limited intermediates have limited exposure potential by definition which together with chronic hazard control language will present no unreasonable risk but will result in real economic savings. 

On the other hand, if a(r) = f(r) the local hardness becomes proportional to the electrostatic potential generated by the molecular Fukui distribution. Since far away from the nuclei the electronic density will be practically equal to the density of the highest occupied molecular orbital pHOMo(r)> and since the Fukui function is closely related to pHOMo(r), one should expect that in this limit both definitions will lead to very similar results. However, at intermediate distances from, and close to, the nuclei they may provide different information on the reactive sites of a chemical species. 

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