Sisomicin structure

Netilmicin Sulfate, USP. Netilmicin sulfate, I -A(-cth)l-sisomicin (Netromycin), is a semisynthetic derivulivc prepared by reductive ethylation of sisomicin. an aminoglycoside antibiotic obtained from Micraiiioiiu pau iiiyoensis. Structurally, sisomicin and netilmicin rc.scniblc gentamicin C . a component of the gentamicin complex. S CHjOH... 

Aminoglycoside antibiotics contain amino sugars in their structure. Deoxystreptamine-containing members are neomycin, framycetin, gentamicin, kanamycin, tobramycin, amikacin, netilmicin and sisomicin. Both streptomycin and dihydrostreptomycin contain streptidine, whereas the aminocycli-... 

Gentamicins A3, B, and Bj bear a hydroxyl group instead of an amine at the C2 -position. Sisomicin 61 and related compounds are derivatives of gentamicin C, which have an unsaturated amino sugar moiety in their structures. Sisomicin is more active than the gentamicin C mixture, but it is also twofold more toxic (compounds... 

Mass spectrometry has been used in structural studies of Gentamicin C and Sisomicin antibiotics. Gentamicin G was separated into three components (Cl, Cia, and C2) by column chromatography. Sugar analysis showed that Sisomycin and the three Gentamicins all contain 2-deoxy-streptamine (51), garosamine (52), and a 2,6-diamino-2,3,4,6-tetradeoxy-hexose (53) [unsaturated in Sisomicin (54)]. " °... 

Aminoglycosides are bactericidal antibiotics with a broad spectmm of antimicrobial activityIn particular, the pseudotrisaccharides of structural type 2 c (Kanamy-cin B, DKB, Amikacin, Tobramycin, Gentamicin C-complex, Sisomicin and Verda-... 

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