Streptamine, 2-deoxy

Chemical Name (S)-0-3-amino-3-deoxy-a-D-glucopyranosyl-(1->6)-0-(6-amino-6-deoxy-a-D-glucopyranosyl-(1->4)] -N -(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine... 

Chemical Name D-Streptamine, 0-3-amlno-3-deoxy-0t-D-glucopyranosyl-(1- 6)-O-[2,6-dl-amino-2,6-dideoxy-0t-D-glucopyranosyl-(1 4)]-2-deoxy sulfate (1 1)... 

Chemical Name 0-3-Amino-3-deoxy-o -D-glucopyranosyl-(1-> 6)-0-[2,6-dlamino-2,3,4,6-tetradeoxy-o -D-erythrohexopyranosyl(1" 4)] -2-deoxy-D-streptamine... 

Chemical Name 0-2-Deoxy-2-(methylamino)-a-L-glucopyranosyl-(1 2)-0-5-deoxy-3-C-(hydroxymethyl)-a-L-lyxofuranosyl-(1 4)-N,N -bis(aminoiminomethyl)-D-streptamine... 

RN 119-04-0 MF C23H46N6OB MW 614.65 EINECS 204-292-2 CN 6>-2,6-diamino-2,6-dideoxy-a-D-gIucopyranosyI(l->4)-0-[0-2,6-diamino-2,6-dideoxy-p-L-idopyranosyl-(l->3)-P-D-ribofuranosyl-(l->5)]-2-deoxy-D-streptamine... 

D-glucopyranosyl- (l->4) -0- [0-02, 6-diamino-2,6-dideoxy-3 L-o idopyranosy 1- (1+3) - 8-D-ribo-furanosyl-c (1+5)] -2-deoxy-D-streptamine. 

Fig. 7 Schematic representation of the conformational differences (highlighted with a dotted box) exhibited by aminoglycosides in the binding pockets of RNA (a) and some of the enzymes involved in bacterial resistance (b). The glucose, 2-deoxy-streptamine and ribose units are numbered as I, II and III respectively...

Following on the discovery of streptomycin and its streptamine-based relatives (Figure 1.2), a new generation of the aminoglycosides derived from 2-deoxy-streptamine (DOS) was not long in coming (Figure 1.3). For a variety of reasons, many of these compounds have not been employed as hnman therapeutics for... 

This enzyme [EC 2.1.4.2] catalyzes the reaction of arginine with l-amino-l-deoxy-xcyZ/o-inositol 4-phosphate to produce ornithine and l-guanidino-l-deoxy-scy//o-inositol 4-phosphate. Other substrates include lo-l-gua-nidino-3-amino-l,3-dideoxy-xcy//o-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate. Canavanine can substitute for arginine. 

Neomycin Neomycin is a complex mixture of antibiotics (neomycins A, B, C, D, E, and F), that is formed by the actinomycete S. fradiae. Neomycin A, also called neamine, is 2-deoxy-4-0-(2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl)-D-streptamine (32.4.2), and it does not display antibiotic properties. At the same time, neomycin B, 0-2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl(l— 4)-0-[0-2,6-diamino-2,6-dideeoxy-)3-L-idopyra-nosyl-(l—>3)-)3-D-ribofuranosyl-(l— 5)]-2-deoxy-D-streptamine (32.4.3), differs from neomycin A in the presence a second glycoside residue and exhibits powerful antibacterial... 

D-STREPTAMINE, 0-2,6-DIAMIN0-2,6-DIDEOXY-alpha-D-GLUCOPYRANDOSYL- (1 -4)-0-(beta-D-RIBOFURANDOSYL-(1-5))-2-DEOXY-... 

---