Simulated moving bed technolog

Gattuso M. J., McCulloch B., House D. W., Baumann W. M., Gottschall K. (1996) Simulated Moving Bed Technology - The Preparation of Single Enantiomer Drugs, Pharm. Tech. Europe 8 20-25. 

D.B. Broughton, Production scale adsorption of liquid mixtures by simulated moving bed technology, Sep. ScL Technol. 19, 723-736 (1984-1985). 

Kearney, M., Simulated Moving-bed Technology Applied to Chromatographic Recovery of Sucrose from Sucrose Syrups, Proc. Sugar Processing Research Conf, 291-304, 1990. 

If all these factors are fulfilled, quite reasonable productivity rates can be achieved. Most separations described so far have been performed in the conventional batch-mode process however, there is growing interest in simulated moving-bed technology, as... 

In recent years, enantioselective chromatography was extended to semipreparative separations and now simulated moving-bed technology (SMB) has become available for the resolution of some synthetic racemates in preparative scale. In the pharmaceutical industry this progress is of considerable interest with respect to enantiopure drug applications. 

Wongso, F., Hidajat, K. and Ray, A. K. (2004). Optimal operating mode for enantioseparation of SB-553261 racemate based on simulated moving bed technology, Biotechnol. Bioeng., 87, pp. 714-722. 

At the time of this writing, there is a renewed interest in simulated-moving-bed technology, and further advancements have been made. Of special interest is the use of supercritical fluids as eluents. 

Gattuso, M.. McCulloch, B. Priegnitz, J.W. UOP Sorbex simulated moving bed technology. A cost effective route to chiral products. Symp. on Chiral Europe, 1994. 

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