Simulated moving bed chromatograph

In a simulated moving bed reactor, as its name already indicates, the movement of the solid phase is simulated. This is achieved by using a set of fixed-bed reactors (columns) connected in series and periodically switching the feed and withdrawal points from one column to the other. A schematic presentation of a simulated moving bed chromatographic reactor is shown in Fig. 8. 

Fig. 8. Schematic presentation of a simulated moving bed chromatographic reactor together with profiles inside the columns. (Reprinted with permission from [131])...

Esterification of glycerin with acetic acid 68 Simulated moving bed chromatographic reactor (SMBCR)... 

Fig. 5.14. Simulated moving-bed chromatographic processes with periodic variation of the feed concentration (ModiCon).

F. Lode, M. Mazzotti, M. Morbidelli, Comparing true countercurrent and Simulated Moving-Bed chromatographic reactors. AIChEJ., 2003,... 

Klatt K.U., Hanisch F. and Dunnebier G., Model-based control of a simulated moving bed chromatographic process for the separation of fructose and glucose, J. Process Contr. 12 (2002) pp. 203-219. 

Strube J., Altenhoner U., Meurer M., Schmidt-Traub, H. and Schulte M., Dynamic Simulation of Simulated Moving-bed Chromatographic Processes for the Optimization of Chiral Separations, J. Chromatogr. A, 769, (1997) pp.8l-92. 

Antia, F. A simple approach to design and control of simulated moving bed chromatographs, Chromatogr. Sci. Series, 2003, 173-202. 

Diinnebier, G., Klatt, K.-U. Optimal operation of simulated moving bed chromatographic separation processes, Comp. Chem. Eng., 1999, 23, 189-192. 

Fricke, J., Schmidt-Traub, H. A new method supporting the design of simulated moving bed chromatographic reactors, Chem. Eng. 

Lode, F., Mazzotti, M., Morbidelli, M. Comparing true countercurrent and simulated moving-bed chromatographic reactors, AIChE /., 2003a, 49, 4, 977-990. 

Miller, L., Grill, C., Yan, T., Dapremont, O., Huthmann, E., Juza, M. Batch and simulated moving bed chromatographic resolution of a pharmaceutical racemate, J. Chromatogr. A,... 

Pai, V. B., Gainer, J. L., Carta, G. Simulated moving bed chromatographic reactors in Fundamentals of Adsorption, LeVan, M. D. (Ed.), Kluwer Academic Publishers, Boston, 1996. 

Jupke, A., Epping, A., and Schmidt-Traub, H. (2002) Optimal design of batch and simulated moving bed chromatographic separation processes. /. Chromatogr. A, 944, 93-117. 

Li, S., Kawajiri, Y, Raisch, J., and Seidel-Morgenstern, A. (2011) Optimization of startup and shutdown operation of simulated moving bed chromatographic processes./. Chromatogr. A, 1218, 3876-3889. 

Kloppenburg, E. Gilles, E.D. Anew concept for operating simulated moving bed chromatographic processes. Chem. Eng. Technol., 1999, 22,10, 813-817. 

Dunnebier, G., I. Weirich, and K. U. Klatt, Conputationally Efficient Dynamic Modeling and Simulation of Simulated Moving Bed Chromatographic Processes with Linear Isotherms, Chem. Engr. ScL, 53, 2537 (1998). 

As hmg as displaceinent liquids are used in liquid bulk-separation processes—be they simulated moving beds, chromatographs, or other configurations—these processes will not be able to compete successfully with distillation for very many of the sqiarations now made by distillation. The problem is one of process complexity, which reflects itself in high invesimem, and energy usage in recovery of the displacement... 

Diinnebier G. and Klatt K.-U. (1999). Optimal Operation of Simulated Moving Bed Chromatographic Processes. Computers Chem. Engng SuppI, 23, pp. S195-S198. 

Strube J, Altenhoner U, Meurer M, Schmidt-Traub H, Schulte M. Dynamic simulation of simulated moving-bed chromatographic processes for the optimization of chiral separations. J Chromatogr A 1997 769 81-92. 

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