Silver compounds absorption

The relative contributions of dermal/ocular absorption, ingestion, and inhalation of silver compounds to the development of these ocular deposits and skin color changes are not known. However,... 

No studies were located concerning the excretion of silver by humans or animals following dermal exposure to elemental silver or silver compounds. Once absorption through the skin and distribution to bodily tissues occurs, it can be expected that elimination would be similar to that of silver absorbed via oral or inhalation exposure, that is, primarily via the feces, with minimal amounts excreted in the urine. 

Absorption, Distribution, Metabolism, and Excretion. The database for inhalation and dermal absorption of silver compounds in humans consists primarily of qualitative evidence from occupational case studies. Limited quantitative information exists on the oral absorption of silver compounds in humans. Research into the quantitative absorption of various silver compounds following relevant exposure routes would be useful to better predict the potential for toxic responses to particular silver compounds in humans. 

Additional research into the comparative absorption, distribution, metabolism, and excretion of different silver compounds would allow a more accurate determination of the effects of silver exposure under specific environmental conditions. The current database primarily provides... 

Studies were located for oral and dermal absorption in animals, but are lacking for absorption from inhalation exposure. Additional animal data would be useful in predicting the rate and extent of the inhalation absorption of various silver compounds in humans. 

Comparative Toxicokinetics. A limited number of studies exist regarding the comparative toxicokinetics of orally administered silver compounds in rats, dogs, monkeys, and humans. A more complete comparison of the absorption and elimination of silver in humans and rats may be warranted given that much of the toxicokinetic data comes from rats. It would also be useful to acquire data on the comparative toxicokinetics of various silver compounds in several species of experimental animals and in humans following inhalation and dermal exposure in order to model the kinetics of silver deposition across different exposure scenarios and within sensitive populations. 

In the presence of substances that react with Ag , the 340 nm absorption decays more rapidly and the rate constant of reaction can be calculated from this decay. It was found in this way that free silver atoms are indeed a strongly reducing species. They reduce Fe to Fe and Cu to Cu (note that these reactions would not occur with the silver atoms at the surface of a compact electrode ) organic compounds containing electrophilic groups such as CICH2COOH or CH3NO2 are reduced by Ag via electron transfer... 

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