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Silencer RNA

RNAi Approach This is the use of short interfering RNA (siRNA, sometimes called small interfering or silencing RNA) to interfere with the expression of a particular gene. The siRNAs are double-stranded RNAs of 20-25 nucleotides. It is envisaged that if the biological pathway of a disease is identified, siRNA could interfere to turn off the activity of the gene involved in the pathway and provide therapeutic effect. [Pg.13]

Baulcombe, D.C. (1 999) Gene silencing RNA makes no protein. Currrent Biology 9, R599-R601. [Pg.431]

Double-stranded RNA-induced gene silencing (RNA interference) Dicer, Ago4, RISC (Paz, Agol,2,3) No disease associated... [Pg.626]

Jackson AL, Burchard J, Leake D, Reynolds A, Schelter J, Guo J, et al. Position-specific chemical modification of siRNAs reduces off-target transcript silencing. RNA 2006 12 1197-1205. [Pg.434]

Ghildiyal M, Zamore PD (2009) Small silencing RNAs an expanding universe. Nat Rev Genet 10 94-108... [Pg.43]

Keywords Antisense Cancer therapy Clinical trials Oligodeoxynucleotides Post-transcriptional gene silencing RNA interference RNase H siRNA... [Pg.153]

See other pages where Silencer RNA is mentioned: [Pg.466]    [Pg.56]    [Pg.58]    [Pg.245]    [Pg.245]    [Pg.466]    [Pg.60]    [Pg.376]    [Pg.38]    [Pg.1084]    [Pg.1145]    [Pg.50]    [Pg.300]    [Pg.307]    [Pg.317]    [Pg.39]    [Pg.39]    [Pg.94]    [Pg.328]    [Pg.33]   
See also in sourсe #XX -- [ Pg.94 ]



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