Sildenafil manufacturing process

In the USA the Presidential Green Chemistry Challenge Awards [7] were introduced to stimulate the application of the principles of green chemistry and many chemical and pharmaceutical companies have received awards for the development of greener processes and products, e.g. Pfizer for developing a greener process for sildenafil manufacture (see Chapter 7). [Pg.410]

In 2003 Pfizer was awarded the Crystal Faraday Award for green chemical technology by the Institute of Chemical Engineers in recognition of the environmentally friendly manufacturing process to make sildenafil citrate. [Pg.276]

Pfizer also received a Crystal Faraday Award for optimizing the process used to manufacture the active ingredient in Viagra , sildenafil citrate. Shown in Figure 3.6 is the solvent usage during each stage of process development for sildenafil citrate over a 15-year lime line [19]. [Pg.58]