Sildenafil Antacids

Clinically important, potentially hazardous interactions with alfuzosin, alprazolam, amphotericin B, anisindione, antacids, aprepitant, astemizole, atorvastatin, bosentan, ciclesonide, cimetidine, clorazepate, conivaptan, cyproterone, dasatinib, dexamethasone, dicumarol, didanosine, eplerenone, erythromycin, ethotoin, fentanyl, fesoterodine, fosamprenavir, fosphenytoin, grapefruit juice, HMG-CoA reductase inhibitors, imatinib, ixabepilone, lapatinib, lopinavir, lovastatin, mephenytoin, methylprednisolone, micafungin, midazolam, nilotinib, pimozide, prednisolone, prednisone, quinidine, rifampin, rimonabant, rivaroxaban, sildenafil, silodosin, simvastatin, sirolimus, solifenacin, temsirolimus, terfenadine, tolvaptan, triazolam, vardenafil, vinblastine, vincristine, warfarin... 

No clinically significant interaction appears to occur between sildenafil, tadalafil or vardenafil and aluminium/magnesium hydroxide antacids. 

In a single dose study in 12 healthy subjects the bioavailability of sildenafil was not affected by single 30-rnL doses of an aluminium/magnesium hydroxide antacid. ... 

Wilner K, Laboy L, LeBel M. The effects of cimetidine and antacid on tiie pharmacokinetic profile of sildenafil citrate in healthy male volunteers. Br J Clin Pharmacol (2007) 53, 31S-... 

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