Signed orders

FIGURE 16. The exciton chirality rule relates the torsion angle or helicity of two electric dipole transition moments (<--->) to the signed order of the CD Cotton effects... 

Although exciton coupling leads to shifted and broadened, if not split, UV-visible spectra of the composite molecule, when the chromophores are held in a chiral orientation, exciton coupling can be detected even more clearly in the CD spectrum as two oppositely-signed CE s typically corresponding to the relevant UV-visible absorption band(s). The signed order of the CD transitions correlates with the relative orientation of the relevant electric dipole transition moments, one from each chromophore, and hence the absolute configuration of the composite molecule (Exciton Chirality Rule.)[2] For the bis-anthra-... 

Orientation, proximity and chromophore are paramount considerations in the Exciton Chirality Rule. Extrachromophoric considerations are relatively unimportant. Thus the CD spectra of bis-p-dimethylaminobenzoates of 5a-cholestan-2a,3/3-diol and (2R,2R)-cyclohex-anediol (both diequatorial diols of the same absolute configuration) are essentially irip.ntir.al (Figure 32). Other steroid diols, whether with vicinal hydroxyls or very distant hydroxyls, give bisignate CE s originating from exciton coupling and with a signed order consistent with the Exciton Chirality Rule (Table XII). 

Supplies of medication will normally take place via a written requisition (colloquially known as a signed order, although the term is somewhat misleading as most written requisitions do not actually need to be signed). However, it is also permissible for some individuals to request medication supply verbally. The oral requisition of medication is covered in Section 5.3. 

As these drugs may be purchased by optometrists from entry level registration and do not necessitate any further training to be undertaken the legislation allows for these medicines to be supplied to optometrists by retail pharmacies on provision of a signed order. A summary of the POMs that can be supplied to optometrists can be found in Table 5.1. Table 5.2 lists P medicines commonly used by optometrists. 

All of the preparations listed in Table 5.3 are available for sale or supply by an optometrist in the course of their professional practice and in an emergency or available from a pharmacy on the presentation of an order signed by a registered ophthalmic optician. On occasion, the signed order may include the intended patient s details as they are the person purchasing the item on the authority of the signed order. 

When optometrists present a signed order for a prescription-only medicine (POM) the following details are required ... 

The signed order may be hand-written, typewritten or computer-generated but it must be in indelible ink. The signature must be original (i.e. not a photocopy or a stamp). 

The master of a vessel registered in the UK will provide a signed order for the purchase of a controlled drug and will keep appropriate... 

Legally (as this is a signed order from an optician) we do not have to label the item. However, professionally we may feel obliged to pass on the dosage instructions from the optician. 

Signed orders apply to sales for purpose of trade, business or profession. The signed order replaces the signature in the poisons register. The order must be given before the sale and state ... 

In an emergency, a Schedule 1 poison may be supplied on an undertaking that a signed order will be supplied within 72 hours. You must be satisfied that ... 

Date Name and Quantity of Poisons supplied Name (a) and Address (b) of Purchaser Business, Trade or Occupation Purpose for which stated to be required Date of certificate (if any) Name and Address of Person giving certificate (if any) Signature of Purchaser or, where a signed order is permitted by the Poisons rules 1982, the date of the signed order Reference No. 

This seems excessive. Can we reduce the number of required experiments The answer is "Yes", if we are willing to give up on higher-order effects. Fractional factorial coefficients offer one method for doing this and require 1/2 2 / or 2/ runs where 1/2 represents the fraction. For example, if we run the half fraction k = 1), this will require only 16 runs. We do this by first preparing a 2 factor design and then we add a fifth column. We shall describe presently how the sign order is determined in this last column. For now, please examine Table 3.12. 

Check that the correct equipment has been received against the original signed order. Go through all of the parts that have been received and check them off against the order. Retain this information. 

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