Signaling transglutaminase

Feng JF, Rhee SG, Im MJ. Evidence that phospholipase delta 1 is the effector in the Gh (transglutaminase II)-mediated signaling. J Biol Chem 1996 271 16,451-16,454. 

Chen S, Lin F, Iismaa S, Lee KN, Birckbichler PJ, Graham RM. a,-adrenergic receptor signaling via Gh is subtype specific and independent of its transglutaminase activity. J Biol Chem 1996 271 32,385-32,391. 

The arARs have been shown to copurify with and activate a high molecular weight G protein, Gh, which is structurally unrelated to heterotrimeric G proteins and has been shown to be the enzyme transglutaminase II (43). This response has been shown to be activated by the a1B- and a1D-, but not the a1A-, subtypes (44). However, the functional significance of this pathway remains unclear because Gh knockout mice show no overt phenotype with respect to arAR signaling (45). 

Nakaoka H, Perez DM, Baek KJ, et al. Gh a GTP-binding protein with transglutaminase activity and receptor signaling function. Science 1994 264 1593-1596. 

Szondy, Z., Molnar, P., Nemes, Z., Boyiadzis, M, Kedei, N., Toth, R., and Fesus, L. (1997) Differential expression of tissue transglutaminase during in vivo apoptosis of thymocytes induced via distinct signalling pathways. FEBS Lett. 404, 307-313. 

Im H-J., Russell M.A. Feng J-F. Transglutaminase II a new class of GTP-binding protein with new biological functions. Cell Signal. 9 (1997) 477 82. 

Joseph B, Lefebvre O, Mereau-Richard C, Danze PM, Belin-Plancot MT, Formstecher P (1998) Evidence for the involvement of both retinoic acid receptor- and retinoic X receptor-dependent signalling pathways in the induction of tissue transglutaminase and apoptosis in the human myeloma cell line RMPI 8226. Blood 91 2423-2432... 

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