Trafficking signaling role

Reiter E, Lefkowitz RJ (2006) GRKs and beta-arrestins roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 17 159-165... 

In addition to the membrane-inserted core domain of Kv channels, their cytoplasmic domains have important roles for Kv-channel function [5]. Many of these functions are related to subunits assembly, channel trafficking to and from the plasma membrane, and interactions with cytoskeletal components (Fig. la). A tetramerization (T) domain for subunit assembly has been well defined in Shaker-channels, where it is localized in the amino-terminus. Other Kv-channels (e.g., eag, HERG, KvLQTl) may have comparable domains within the cytoplasmic carboxy-terminus. ER retention and retrieval signals have been found... 

Aronin N, DiFiglia M (1992) The subcellular localization of the G-protein Gi alpha in the basal ganglia reveals its potential role in both signal transduction and vesicle trafficking. J Neurosci 12 3435—3444... 

Chan, Y. and Jan, Y.N. Roles for proteolysis and trafficking in Notch maturation and signal transduction (1998) Cell 94, 423-426... 

Discussion of the roles of phosphatidylinositol derivatives in signal transduction, cytoskeletal regulation, and membrane trafficking. 

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